What are some of the complications in designing trials to study partially effective AIDS vaccine candidates?
UNDERSTANDING HIV TRANSMISSION
January 2008
What events lead to the sexual transmission of HIV and how can muscosal immune responses protect against infection?
UNDERSTANDING REPLICATING VIRAL VECTORS
December 2007
What are the advantages of using replicating viral vectors in AIDS vaccine research?
UNDERSTANDING IMMUNOGENICITY
August 2007
How do researchers measure the immune responses induced by AIDS vaccine candidates?
UNDERSTANDING HIV INCIDENCE
July 2007
Why are HIV incidence rates important for AIDS vaccine trials?
UNDERSTANDING PARTIALLY EFFECTIVE AIDS VACCINES
May 2007
What is a partially effective vaccine and how can it limit the spread of HIV?
UNDERSTANDING THE CHALLENGES OF AIDS VACCINE DEVELOPMENT
April 2007
What are the major scientific obstacles to the development of an effective AIDS vaccine?
UNDERSTANDING WHY AN EFFECTIVE AIDS VACCINE IS FEASIBLE
March 2007
What evidence exists for immune control of HIV/SIV?
UNDERSTANDING NEUTRALIZING ANTIBODIES
February 2007
Why are HIV-specific neutralizing antibodies so difficult to induce with vaccination?
UNDERSTANDING IMMUNE CORRELATES OF PROTECTION, PART II
December 2006
How can animal models be used to identify the correlates of protection for an AIDS vaccine?
UNDERSTANDING IMMUNE CORRELATES OF PROTECTION, PART I
November 2006
How can researchers identify the correlates of protection for an AIDS vaccine?
UNDERSTANDING AIDS VACCINE PRE-CLINICAL DEVELOPMENT
October 2006
How are AIDS vaccine candidates tested for safety and immunogenicity before they enter clinical trials?
UNDERSTANDING LONG-TERM NONPROGRESSORS
September 2006
What can AIDS vaccine researchers learn from studying people who are HIV infected but progress more slowly to AIDS?
UNDERSTANDING HIV CLADES
July 2006
How does the genetic diversity of HIV affect AIDS vaccine design?
UNDERSTANDING THE EARLY STAGES OF HIV INFECTION
April 2006
How can studying what happens immediately following HIV infection help researchers design an AIDS vaccine?
UNDERSTANDING MUCOSAL IMMUNITY
December 2005
How could the need to assess mucosal immunity affect AIDS vaccine trials?
UNDERSTANDING PRE-EXISTING IMMUNITY
February 2005
What is pre-existing immunity to a vaccine vector?
UNDERSTANDING VACCINE ADJUVANTS
October 2004
How are vaccine immune responses strengthened?
UNDERSTANDING VIRAL VECTORS
September 2004
Why use viral vectors for AIDS vaccines?
UNDERSTANDING THE SEXUAL TRANSMISSION OF HIV
June 2004
How does sexual transmission happen and how can it be blocked by vaccines or microbicides?
UNDERSTANDING PARTIAL EFFICACY
May 2004
What is a partially effective vaccine?
UNDERSTANDING VACCINE DEVELOPMENT
April 2004
How do AIDS vaccines prepare different parts of the immune system to fight HIV?
UNDERSTANDING THE IMMUNE SYSTEM, PART II
March 2004
How are vaccines developed?
UNDERSTANDING THE IMMUNE SYSTEM, PART I
February 2004
How do vaccines interact with the immune system?
UNDERSTANDING ROUTES OF TRANSMISSION
October 2003
Why do vaccines need to be tested in different populations?
UNDERSTANDING VIRAL DIVERSITY
September 2003
Why are there so many different versions of HIV?