VAX Online Primers:
- UNDERSTANDING LIVE-ATTENUATED VACCINES -
June 2008
What can AIDS vaccine researchers learn from live-attenuated SIV vaccines? - UNDERSTANDING THE RECRUITMENT OF VOLUNTEERS AT RISK OF HIV INFECTION -
May 2008
Why are volunteers who are at high risk of HIV infection necessary participants in late-stage AIDS vaccine trials? - UNDERSTANDING CELLULAR IMMUNE RESPONSES -
April 2008
What is known about cellular immune responses against HIV? - UNDERSTANDING THE RECRUITMENT AND RETENTION
OF WOMEN IN CLINICAL TRIALS -
March 2008
What are some of the considerations regarding recruitment and retention of women in AIDS vaccine clinical trials? - UNDERSTANDING BIOSTATISTICS AND THE STEP TRIAL -
February 2008
How are statisticians analyzing the data from the STEP trial? - UNDERSTANDING HIV TRANSMISSION -
January 2008
What events lead to the sexual transmission of HIV and how can muscosal immune responses protect against infection? - UNDERSTANDING REPLICATING VIRAL VECTORS -
December 2007
What are the advantages of using replicating viral vectors in AIDS vaccine research? - UNDERSTANDING RANDOMIZED, CONTROLLED CLINICAL TRIALS - October-November 2007
What are randomized, controlled, double-blind clinical trials? - VAX SPECIAL REPORT - September 2007
What immediate implications does the cessation of immunizations in the STEP trial have for the AIDS vaccine field? - UNDERSTANDING IMMUNOGENICITY - August 2007
How do researchers measure the immune responses induced by AIDS vaccine candidates? - UNDERSTANDING HIV INCIDENCE - July 2007
Why are HIV incidence rates important for AIDS vaccine trials? - UNDERSTANDING DATA SAFETY MONITORING BOARDS - June 2007
How do DSMBs monitor ongoing clinical trials? - UNDERSTANDING PARTIALLY-EFFECTIVE AIDS VACCINES - May 2007
What is a partially-effective vaccine and how can it limit the spread of HIV? - UNDERSTANDING THE CHALLENGES OF AIDS VACCINE DEVELOPMENT - April 2007
What are the major scientific obstacles to the development of an effective AIDS vaccine? - UNDERSTANDING WHY AN EFFECTIVE AIDS VACCINE IS FEASIBLE - March 2007
What evidence exists for immune control of HIV/SIV? - UNDERSTANDING NEUTRALIZING ANTIBODIES - February 2007
Why are HIV-specific neutralizing antibodies so difficult to induce with vaccination? - UNDERSTANDING IMMUNE CORRELATES OF PROTECTION (PART II) - December 2006
How can animal models be used to identify the correlates of protection for an AIDS vaccine? - UNDERSTANDING IMMUNE CORRELATES OF PROTECTION (PART I) - November 2006
How can researchers identify the correlates of protection for an AIDS vaccine? - UNDERSTANDING AIDS VACCINE PRE-CLINICAL DEVELOPMENT - October 2006
How are AIDS vaccine candidates tested for safety and immunogenicity before they enter clinical trials? - UNDERSTANDING LONG-TERM NONPROGRESSORS - September 2006
What can AIDS vaccine researchers learn from studying people who are HIV infected but progress more slowly to AIDS? - UNDERSTANDING HIV CLADES - July 2006
How does the genetic diversity of HIV affect AIDS vaccine design? - UNDERSTANDING HOME-BASED VOLUNTARY COUNSELING AND TESTING - June 2006
How can home-based or mobile services for HIV counseling and testing improve community responses? - UNDERSTANDING REFERRAL NETWORKS IN AIDS VACCINE TRIALS - May 2006
What is the process for referring volunteers in vaccine trials for treatment and care? - UNDERSTANDING THE EARLY STAGES OF HIV INFECTION - April 2006
How can studying what happens immediately following HIV infection help researchers design an AIDS vaccine? - UNDERSTANDING CAPACITY BUILDING AT VACCINE TRIAL SITES - March 2006
How can AIDS vaccine trials help build infrastructure and capacity in developing countries? - UNDERSTANDING THE BENEFITS AND RISKS OF PARTICIPATING IN CLINICAL RESEARCH - February 2006
What are the major considerations influencing the decision to volunteer for an AIDS vaccine trial? - UNDERSTANDING MUCOSAL IMMUNITY - December 2005
How could the need to assess mucosal immunity affect AIDS vaccine trials? - UNDERSTANDING HIV TESTING - November 2005
How can participation in an AIDS vaccine trial affect HIV test results? - UNDERSTANDING COUPLES VOLUNTARY COUNSELING AND TESTING - October 2005
Why is voluntary counseling and testing for couples an important process for recruiting women into vaccine trials? - UNDERSTANDING TEST OF CONCEPT TRIALS - September 2005
Why are Phase IIb trials an important step in evaluating AIDS vaccine candidates? - UNDERSTANDING RISK-REDUCTION COUNSELING - August 2005
Why is risk-reduction counseling an important part of AIDS vaccine trials? - UNDERSTANDING INFORMED CONSENT - June 2005
How does the informed consent process work in vaccine trials? - UNDERSTANDING COMMUNITY ADVISORY BOARDS - May 2005
What role do Community Advisory Boards have in vaccine trials? - UNDERSTANDING RESEARCH VOLUNTARY COUNSELING AND TESTING - April 2005
How is voluntary counseling and testing provided to volunteers in clinical research or vaccine trials? - UNDERSTANDING CLINICAL RESEARCH STUDIES - March 2005
What information can clinical research studies provide? - UNDERSTANDING PRE-EXISTING IMMUNITY - February 2005
What is pre-existing immunity to a vaccine vector? - UNDERSTANDING VACCINE ADJUVANTS - October 2004
How are vaccine immune responses strengthened? - UNDERSTANDING VIRAL VECTORS - September 2004
Why use viral vectors for AIDS vaccines? - UNDERSTANDING THE SEXUAL TRANSMISSION OF HIV - June 2004
How does sexual transmission happen and how can it be blocked by vaccines or microbicides? - UNDERSTANDING PARTIAL EFFICACY - May 2004
What is a partially effective vaccine? - UNDERSTANDING VACCINE DEVELOPMENT - April 2004
How do AIDS vaccines prepare different parts of the immune system to fight HIV? - UNDERSTANDING THE IMMUNE SYSTEM (PART II) - March 2004
How are vaccines developed? - UNDERSTANDING THE IMMUNE SYSTEM (PART I) - February 2004
How do vaccines interact with the immune system? - UNDERSTANDING TRIAL APPROVAL - November 2003
How does an AIDS vaccine trial gain official approval and community support? - UNDERSTANDING ROUTES OF TRANSMISSION - October 2003
Why do vaccines need to be tested in different populations? - UNDERSTANDING VIRAL DIVERSITY - September 2003
Why are there so many different versions of HIV? - UNDERSTANDING VACCINE TRIALS - August 2003
How are AIDS vaccines tested?